Left Ventricular Diastolic Function after Anthracycline Chemotherapy

Background and Anthracycline is a topoisomerase-interacting agent that is used in treatment of many cancers. We investigated the effects of anthracycline in adults using conventional echocardiography and pulse tissue Doppler imaging.
This observational before-after study was performed in 35 patients being recently diagnosed with cancer for whom ANT therapy was planned. Echocardiography studies were performed before chemotherapy and 6 months after initiation of the study. Additionally, troponin I and creatinine kinase-MB (CK-MB) were measured one month after the initiation of chemotherapy.
Six months after anthracycline therapy, Changes were seen in the systolic and diastolic left ventricular (LV) function. LV ejection fraction significantly decreased (P Altered LV systolic and diastolic function was observed after anthracycline chemotherapy.