Protective effect of green tea extract on ovary tissue function in rats treated by Malathion insecticide

This study was conducted to investigate the protective effect of green tea extract on ovary tissue performance in rats treated by Malathion insecticide.
In this research, 72 Wistar mature rats with ages of 2 to 3 months (approximate weight of 200±15 g) were experimented. Animals were divided into 9-octet groups of animals. Control group did not receive any medication. Control group was given 0.2cc physiological serum and experimental 1, 2 and 3 received 100, 200 and 400 mg/KG B.W. green tea extract respectively, the experimental 4 was given 40 mg/KG B.W. Malathion and the experimental 5,6 and 7 each received 100, 200 and 400 mg/KG B.W. tea extract respectively and 40 mg/KG B.W. Malathion. After 15 days, the rats’ hearts were blooded, and the sex hormones concentration was measured by the prepared serum. Ovaries were then separated to count the ovarian follicles.
Concentration of Estrogen, Progesterone, FSH and LH were significantly decreased in experimental group 4,compared to control and other groups. The primary and Graf follicles in experimental group 4 decreased and in experimental groups 2 and 3 significantly increased in comparison to control group. Atresia folliclesa had a significant increase in experimental group 4,compared to other groups. Primary and secondary follicles’ and corpus luteum in experimental group 4 significantly decreased compared to control group.
Malathion had an adverse effect on secretion of sex hormones in female rats, as well as the process of oogenesis, and green tea extract decreased those negative effects.