Repair ethanol induced amnesia with Iranian lactobacillus brevis in Rats

Animal studies show that ethanol exerts amnesic effects in different models of memory such as inhibitory avoidance.Probiotics are food supplements and pharmaceutical substances prepared from living microorganisms that with enhancement of microbial equilibrium of intestinal microbiota,insert useful effects on the host (human/animal. The aim of this study was examination of TD4, the native Iranianprobiotic isolated from Traditional dairy product on the rat passive avoidance. In this study use as 96 male wistar rats with 200-250 grams weight range. For induced amnesia used as ethanol and for one mount administrated with1×10 9 cfu/ml of with or without probiotic bacteria.The step-through passive avoidance used in the present study to examine long-term memory in male Wistar rats. Results indicate that post-training sub cortical (SC) administration of etanol (1 mg/kg) induce amnesia. This amnesia was reversed in probiotic receiving groups. Results of this study showed that the lactobacillus brevisisolated fromTarkhineh dough, enhance the on passive avoidance learning of male Wistar rats that resiveetanol. Our data demonstrate the positive effect of this probeotic on learning and memory.