The Effect of Hydroalcoholic Extract of Salvia Officinalis on Blood- Brain Barrier Permeability and Neuromotor Deficits in Male Rat Transient Ischemic Model

In the early stages of brain ischemia, the production of free radicals increases. Salvia officinalis is a rich source of antioxidant compounds. Therefore, in this study the effects of hydroalcoholic extract of Salvia officinalis on blood -brain barrier permeability and neurological deficits have been studied.
In this experimental study 35 male Wistar rats were randomly divided into 5 groups of 7 rats. The control group received distilled water; three groups received hydroalcoholic extracts of Salvia officinalis, respectively with doses of 50, 75 and 100 mg/kg for, 3 weeks intraperitoneally; The sham group was not treated and was not induced bybrain ischemia. Thereafter, the first four groups underwent middle cerebral artery occlusion 2 hours after the last injection and were induced by focal cerebral ischemia model, then blood- brain barrier permeability, and neurologic deficits were investigated.. Data were analyzed using one-way ANOVA.
The hydroalcoholic extract of salvia could reduce permeability of the blood-brain barrier in three doses of 50 (10.68±0.54), 75 (5.87±0.41) ,and 100 mg/kg (5.19±0.49) compared with the control group (p=0.018, p These results indicate that Salvia officinalis can make a guardianship in front of brain ischemia because it reduces blood- brain barrier permeability and neurologic deficits.