Comparison of CNS suppressive effects of oral ketamine & cyproheptadine in cat

The aim of this study was to evaluate of liquid form of ketamine and cyproheptadine CNS suppression effects via of single or together in cat.Ten street male & adult cats were selected and in the first stage received drugs [ketamine (20, 40, 80 mg/kg) & cyproheptadine (1,2,4mg/kg)] in mixture of milk (40ml), meat (30g) or sublingual spray route. In second stage they received concomitant doses of Cyproheptadine & ketamine by the mentioned method. In each stage CNS depression effects ofregimes recorded by an educated observer and weregraded in 5 scales. Almost all of the animals rejecteddrugs in mixture of milk and meat. So sublingual spray rout used for oral administration.Cyproheptadine, individually, in sublingual spray administration did not show any significant CNS depression effects, however, ketamine did it as a dose dependent. In addition, depth and duration of CNS depression increased by concomitant use of Cyproheptadine with ketamine in compare of ketamine. Results showed that administration of ketamine & Cyproheptadine in mixture of milk & meat is not a suitable method in cats. But a strong and long time CNS depression is achieved when ketamine is sprayed in mouth (as sublingual form).