The Weakening Effects of Aqueous Extract of Cinnamomum Verum on Learning and Spatial Memory in Streptozotocin-Induced Diabetic Male Rats

Cinnamom (Cinnamonum verum) has therapeutic effects such as anti-diabetic, decreasing of weight and blood lipid and sugar. The aim of this study was to evaluate the effect of aqueous extract of Cinnamon on learning and spatial memory in streptozotocin-induced diabetic rats.
In this study, 28 adult male Wistar rats weighting 200 ± 30 g were used. Rats were divided into four groups: control (C), control receiving extract (C), diabetic (D), diabetic receiving extract (D). Diabetes was induced by intraperitoneal injection of 50 mg/kg streptozotocin. The experiments were assigned to 3 weeks. In this time, the treatment of extract was carried out in a dose of 200 mg/kg. At the end of experiment the weight of the treated rats was compared to control groups. Evaluation of learning and spatial memory was done using radial eight-arm maze. The data were analyzed using repeated measure ANOVA by SPSS software.
Findings: The significant (P The aqueous extract of cinnamon attenuates the learning and the spatial memory of diabetic rats, probably due to increase of blood sugar and its destructive effects on nervous system function.