Effects of Isradipine on Induced-Parkinson's Disease in Rats
Author(s):
Abstract:
Background
Parkinsons disease is the second most common neurodegenerative disease in developed countries. Recent studies have showed that there is a relation between neuron loss in Parkinsons disease and L-type calcium channel activity in pars compacta of substantia nigra. Therefore, it seems that calcium channel blockers can effect on this disease.Objectives
In this study, we evaluate the protective and therapeutic effects of isradipine on experimental Parkinsons model in rats.Materials And Methods
In this experimental study, 63 rats were allocated randomly in seven group including: intact, control, sham operated, lesion and lesion treated by 0.1, 0.2 or 0.4 mg/kg dosage of isradipine. L-type calcium channel blocker, isradipine was subcutaneously injected to treated rats in the doses of 0.1, 0.2 and 0.4 mg/kg/day, for four weeks, starting the day after a unilateral nigrostriatal 6-hydroxy dopamine (6-OHDA) lesion. Rotational tests with apomorphine and rigidity tests were conducted on all animal groups one week before the lesion experiments and four weeks after.Results
Administration of isradipine (0.1, 0.2 and 0.4 mg/kg/day for 4 weeks) decreased mean of rotation number and muscular rigidity score significantly compared with control group (P Conclusions
This study showed that isradipine has a therapeutic effect in a dose dependent manner on Parkinsons disease in rats. Keywords:
Language:
English
Published:
Zahedan Journal of Research in Medical Sciences, Volume:18 Issue: 4, Apr 2016
Page:
9
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