Effects of garlic extract, olive leaf extract, nettle extract on serum inflammatory markers hsCRP and IL-6 and TNF-α in rats with diabetes

It has been demonstrated that the inflammatory markers such as IL-6, TNF-α and CRP are increased in STZ-diabetic rats. The present study is to investigate the effects of medicinal plants used in traditional medicine, including garlic extract; nettle leaves extract and olive extract on serum hsCRP and IL-6 and TNF-α on the rats with diabetes.
Diabetes was induced in male wistar rats by single injection streptozotocin (60 mg/kg). Garlic extract, nettle leaves extract and olive extract were used one day after induction of diabetes until three weeks after STZ-diabetes induction. In this study the animals were divided into five groups: control, diabetic, diabetic garlic extract (50 mg / kg), diabetes Nettle leaf extract (30 mg / kg), and diabetes Olive extract (30 mg / kg). After 21 days, serum levels of inflammatory factors were measured using ELISA kits.
The results showed that the serum levels of hsCRP and IL-6 and TNF-α in the target groups, the use of medicinal plants extracts, as compared to untreated diabetics have significantly decreased.
The results showed that administration of garlic extract, nettle extract and olive extract significantly attenuated levels inflammatory markers such as IL-6, TNF-α and CRP in diabetic rats.