Stereological study on the effect of vitamin C in preventing the adverse effects of bisphenol A on rat ovary

Bisphenol A (BPA), an environmental pollutant, can generate free radicals which damages the reproductive system. Vitamin C is an antioxidant which may prevent the adverse effects of free radicals.

The aim was to investigate the effect of vitamin C on the ovary tissue in rats treated with BPA.

In this experimental study, 24 female Wistar rats (200±20 gr) were randomly divided into 4 groups (n=6): control, BPA (60 µg/Kg/day), vitamin C (150 mg/Kg/day) and BPA vitamin C and orally treated for 20 days. The left ovaries were taken out, fixed for tissue processing and studied using stereological methods. Data were analyzed with SPSS using one-way ANOVA, and the means were considered significantly different at (p

The total volume of ovary and cortex (p

Vitamin C can be used as a potential antioxidant in the case of BPA toxication.