Survey of effect of MTBE on Reproductive performance in female rat

Methyl tert- butyl ether chemicals that belong to the group and its chemical formula is C5H12O. To evaluate the effects of MTBE on the reproductive and hormonal factors were female rats. MTBE guess is that the endocrine system and affect glands in the body and may also affect reproduction. 90 Wister Albino (Surrey) female strain Balb / C 90 days from the Pasteur Institute, Tehran was prepared. Randomly rats in 6 groups with 3 replicates were divided. Groups, (the control group stressed canola oil and water routine), placebo (under Cadmium chloride), treatment 1 (100 mg / kg / day MTBE), treatment 2 (200 mg / kg / day MTBE), Treatment 3 (1000 mg / kg / day MTBE), treatment 4 (200 mg / kg / day MTBE), respectively. From each group of mice on days (17, 21, 45, 90) were measured after the initial blood tests, At the end of 2 mice from each group were killed by ether, ovaries and ovarian tissue was examined histological. Serum concentrations of LH, FSH, E2, progesterone, and cholesterol were measured. MTBE impact on fertility test goes rates numbers of newborn female rats were examined after birth. SAS 98 software for statistical analysis and comparison between the average data of the Duncan test was used. MTBE estrogen concentration (P