Comparative evaluation of Garlic and Atorvastatin effects on lipid profile changes in dog

The purpose of the present study was to evaluate the effects of garlic and atorvastatin on lipid profile changes in dogs and the influence of time on treatment process. For this purpose, 15 male dogs, 1- 2 years old were randomly divided into 3 groups with 5 animals in each group. Group A (control) included five dogs were fed with cholesterol powder (4 g/kg for 10 days) to induce hyperlipidemia. Group B was similar to group A, but in addition cholesterol, atorvastatin (5 mg/kg) was administered for 45 days. Group C was similar to group B, with the difference that garlic (100 mg/kg body) was administered instead of atorvastatin. Blood samples were collected four times during zero, 10, 40 and 55 days after start of study. Serum total cholesterol, triglycerides, HDL-C and LDL-C were measured by using commercial kits. Atorvastatin (p