The Effects of Inflammatory Tooth Pain on Anxiety in Adult Male Rats

This study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats.
The mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. Formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. Diazepam treated group received diazepam 30 minutes before intradental injection. The anxietyrelated behavior was evaluated with elevated plus maze test.
Intradental application of chemical noxious stimuli, capsaicin and formalin, significantly affected nociceptive behaviors (P Inflammatory pulpal pain has anxiogenic effect on rats, whereas diazepam premedication showed both anxiolytic and pain reducing effects.