Study of the Anxiolytic Effects of Plantgo major L. and Possible Role of Gabaergic System in these Effects in Rats

Inroduction & Anxiety is a common mental disorders among human populations is considered. Due to the side effects of chemical drugs used to treat them, this study aimed to investigate plantago major leaf extract on the level of anxiety in rats was performed.
Material and In this experimental study, 42 male Wistar rats were used. Animals were divided in 6 groups: negative control group (normal saline), positive control group (diazepam 1 mg/kg) and 4 treatment groups with plantago major leaf extract (doses of 25, 50, 100 and 200 mg/kg). Elevated plus-maze test was used to assess anxiety. Data using one-way ANOVA and Duncan's post hoc test and a significance level of P The results of this study showed that plantago major leaf extract at doses of 50, 100 and 200 mg/kg causes anxiolytic effects in the elevated plus-maze test and 100 mg/kg significantly (P According to the results of this study, it seems that plantago major leaf extract due to containing the flavonoid compounds have anxiolytic effects and this effect may be made through the of GABAergic system.