The Effect of Curcumin on Liver of Stradiol Valerate -induced Polycystic Ovarian Syndrome Wistar Rat

Polycystic ovarian syndrome (PCOS) is endocrine insufficiency that affects liver structure in many cases and finally leads to liver necrosis, fibrosis and Cirrhosis. Curcumin, the major constituent in the rhizome of Curcuma longa, has anti-oxidant effects and protects liver tissue. In this experimental study we aimed to evaluate the effects of curcumin on liver dysfunction of PCOS induced rat as an anti-inflammatory therapeutic agent. For this purpose, 90 mature female Wistar rats were divided into control (no injection) and PCOS groups (exposed to subcutaneously administration of estradiol valerate for PCOS induction). PCOS rats were divided into control and experimental groups received 14 days intraperitoneal injection curcumin (300 mg/kg BW). Animals were killed and Liver and serum were taken for histomorphometric examination and serum CRP, stradiol and testostron level. The data were analyzed using One-Way ANOVA with P3.567 significance level. Serological assays and Hematoxylin & eosin-stained liver showed that the serum CRP, stradiol and testostron level and also number of Kupffer and damaged or necrotic hepatocytes significantly increased in PCOS compare to control. Whereas, the number of necrotic and kupffer cells decreced in Curcumin-treated groups compared to PCOS. Also, the levels of LDL, triglyceride increased in PCOS group compare to the control group but reduced in curcumin-treated group. Whereas, the levels of HDL and cholesterol decreased in PCOS group compare to the control group but increased in curcumin treatment group. In conclution, we suggest that curcumin has beneficial effect on inflammatory features of PCOS in liver via anti-inflammatory effects.