Comparing the Performance of Five Brain Systems and mood changes(Anxiety and depression) with the Level of Estrogen in Postmenopausal and Premenopausal Women of Esfahan

One of the most critical stages of women’s lives is menopause. It is caused by permanent cessation of ovarian function and decline of estrogen level. Menopause has numerouse side effects (Physical and psychological). Recent neurophysiological data suggest that the function of central nervous system may be susceptible to modulation by estrogen. The aim of this study was to compare the performance of the five important parts (prefrontal cortex, cingulate gyrus, limbic system, basal ganglia and temporal cortex) of the brain and mood changes (anxiety and depression) with the level of estrogen in postmenopausal and premenopausal women in Isfahan.
The research was descriptive. The statistical Sample was 200 women (100 postmenopausal women 45 to 65 years old, and 100 premenopausal women, 20 to 40 years old) who were selected by non-random available sampling method in Sajjad and Motahari health centers and Amin and Asgarieh hospitals. Beck Depression Inventory-Secsend Edition (BDI-II) (r=0.93), Beck Anexity Inventory (r=0.92) and Amenʼs questionnaire of brain systems (r=0.89) which was designed to assess five brain parts (prefrontal cortex, cingulate gyrus, limbic system, basal ganglia and temporal cortex) were used to collect data. To analyze the data, descriptive statistics (mean and standard deviation) and inferential statistics (MANOVA) was performed using the software Spss22.
Significant differences were found in the function of the brain systems (prefrontal cortex, cingulate gyrus, limbic system, basal ganglia and temporal cortex) and levels of estrogen and anexity between two the groups postmenopausal and premenopausal women (P0/001).
It seems that in addition to the role of estrogen in women's sexual and reproductive impact on the nervous system and its parts and function of five brain systems reduced after menopause due to reduction in the protective effects of estrogen. So that they can be two-way communication and convergence between secretes hormones and brain function and mood changes such as anxiety and depression explained.