The study of insecticidal effect of new phosphoramide compounds on some insect pests
Some derivatives of phosphoramide compounds are able to inhibit acetylcholinesterase (AChE) and therefore could be considered as insecticides. In this study, insecticidal effects of eleven phosphoramide compounds have been tested on Aphis craccivora Koch, Xanthogaleruca luteola Müller, Glyphodes pyloalis Walker and Achropus rosae Linnaeus. Among these compounds, (propylene -N, N'-bis (O, O' diethyl phosphoramidothioate) showed the highest insecticidal effect and the amount of LC50s were obtained as 3174.28, 2536.27, 3474.69 and 3627.43 mg/ml for A. craccivora, X. luteola, G. pyloalis and A. rosae, respectively. The activities of AChE and general esterases in the insects treated with these compounds were measured. Similarly the I50 of these compounds were determined in vitro on AChE activity in each insect. The results showed the lowest I50 to propylene-N, N'-bis (O, O' dimethyl phosphoramidothioate) on G. pyloalis. Today, direct relationship between chemical structure and biological activity (QSAR) has been proven. According to the information obtained from this study, we can focus on insecticidal effect of (propylene -N, N'-bis (O, O' diethyl phosphoramidothioate) derivatives in future for finding of new insecticides.