Association of GADD45A Gene Polymorphism with Systemic Lupus Erythematosus Disease among Patients in South of Iran

Systemic lupus erythematosus (SLE) is an autoimmune disease with broad clinical manifestations, but unclear etiology. Extensive tissue damage occurs due to the production of auto-antibody against nuclear and cytoplasmic antigens. Regarding the involvement of GADD45A gene in cell cycle control, T-cell proliferation suppression, and genome epigenetic regulation, this case-control study was done for the first time to evaluate the association of rs581000 polymorphism in 5’ near gene with the risk of SLE among patients in south of Iran.
This study was performed on 102 patients with SLE in comparison with 118 healthy controls. Genotyping of the GADD45A rs581000 polymorphism was performed using T-ARMS PCR.
The T allele was significantly more frequent in the controls (0.13) than in the patients (0.01) with SLE (p It seems that GADD45A rs581000 polymorphism involved in the SLE pathogenesis.