Evaluating the Role of Omega 3 on the Side Effects of Isotretinoin in Patients with the Acnea Vulgaris
Author(s):
Abstract:
Background
Acne vulgaris is chronic inflamatory disease of the pilosebaceous unit.Patients experience psychological burdens like depression ,anxiety , and low self-esteem. Isotretinoin is used in the treatment of severe ,recalcitrant acne ;however,treatment commonly results in associated with a number of adverse effects that treatment stopped consequent this side effects. The aim of this study is to evaluate the effect of oral omega 3 on side-effects of isotretinoin .Methods
One hundred eighteen patients with sever acne vulgaris were randomized to two groups. Control group recived isotretinoin (0.5 mg∕kg) alone and case group received isotretinoin (0.5 mg∕kg) combined with omega 3 (2 capsuls) daily.the treatment duration was 16 weeks.Mucocutaneous side-effects were assessed(4,8,12,16th wk).Results
Lip dryness (4,8,12th wk) and dryness of nose, skin ,eye in the 4 th week in the patients treated with isotretinoin and omega3 was lesser than in the patients treated with isotretinoin (P value Conclusion
Omega 3 decreased the mucocutaneous side effects in the patients with acne vulgaris who received isotretinoin.Keywords:
Language:
Persian
Published:
Journal of Arak University of Medical Sciences, Volume:19 Issue: 10, 2017
Pages:
81 to 87
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