Serum levels of homocysteine, adiponectin and uric acid in gestational diabetes mellitus compared with normal pregnancy

There are low and conflicting data about the relationships between homocysteine, adiponectin/ homocysteine ratio and uric acid with insulin resistance indexes in gestational diabetes mellitus (GDM). Therefore, this study was performed with aim to evaluate serum values of homocysteine, adiponectin, adiponectin/ homocysteine ratio and uric acid and their relationships with insulin resistance index in GDM compared with normal pregnancy.
This cross-sectional study was performed on 30 women with GDM and 30 normal pregnant women referred to Asalian hospital of Khorramabad during 2013-2014. Serum levels of glucose and uric acid were measured by photometric method and serum levels of homocysteine, adiponectin and insulin were measured by ELISA method. Data was analyzed by independent t-test and Pearson’s correlation analysis. P
Serum levels of homocysteine were significantly increased in GDM compared with normal pregnant women (P Increased serum values of homocysteine and decreased values of adiponectin/ homocysteine ratio and lightly increased levels of uric acid could be considered as risk factors for insulin resistance in GDM.