Effects of 12 weeks resistant training on MTNR1B gene expression in the pancreas and glucose and insulin levels in type 2 diabetic rats

Type 2 diabetes is a multifactorial disease, but recently it has been found that increased expression of MTNR1B gene is associated with of the risk of type 2 diabetes. The aim of this study was to evaluate the effect of 12 weeks of resistance training on MTNR1B gene expression in the pancreas and glucose and insulin levels in male Wistar rats with type 2 diabetes.
This study was a fundamental and experimental approach. In this study 30 male Wistar rats weighing 220±20 g, were used. Rats were kept under the standard conditions of temperature of 22 °±2 C and humidity of 45% and consecutive 12-hour periods of light and darkness. Rats were divided into three groups: Control group, diabetic group, and diabetic plus resistant training group. Diabetes was induced by disolving nicotinamide and STZ in the drinking water. Resistance training was conducted for 12 weeks, 5 days a week in a 3 course with 6 repetitions. All rats were sacrificed 48 hours after the last training session.
A significant reduction in fasting glucose levels was observed in the diabetic resistant training group than the diabetic group (P The results showed that twelve weeks of resistance exercise significantly increased serum insulin, a significant reduction in blood glucose and a significant reduction in the MTNR1B gene expression in the pancreatic than diabetic group.