Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats

In this study, the protective effect of Iranian Golpar on the acute hepatotoxicity due to acetaminophen over doses has evaluated. 80 Wistar male rats were randomly divided in to 4 groups (n=5). Control groups used tap water in 14 days following DMSO i.p injection at day 15th. Acetaminophen groups received tap water in 14 days following 500 mg/kg b.w. injection of acetaminophen (i.p) dissolved in DMSO. Treatment groups received Golpar essential oils (100 and 200 mg/kg b.w) in 14 days following acetaminophen injection at day 15th. Then, the concentration of glutathione (GSH), proxidasion lipids (MDA) and the total antioxidant capacity of plasma and the activity of glutathione s-transferase (GST) with biochemical methods were estimated. Indeed, the levels of liver enzymes; alanin Teransferase (ALT), aspartate Teransferase (AST), and alkaline phosphatase ALP of the serum were measured. Hence, the histopathology assessments were performed in the liver. The results of the study showed that the Golpar essential oil could significantly prevent from decreasing of GSH, GST and FRAP and increasing of the liver enzymes and prooxion lipids after severe acetaminophen toxicity. Also, the histopathological findings of the liver tissue was confirmed the above results. Therefore, the Golpar essential oil could remarkably protect the liver tissue against the stress oxidative induced by acetaminophen.