Effects of Prosopis Farcta Hydro-Alcoholic Seed Extract on Thioacetamide-Induced Acute Liver Toxicity in Rats

In this survey, the protective effect of Prosopis farcta seed hydro-alcoholic extract against acute hepatotoxicity induced by thioacetamide in rat was studied.
30 male rats were equally divided to 3 groups. The first group received normal saline orally. The second and third group received thioacetamid (50 mg/kg intraperitoneally) three times at an interval of 24 hours. Rats in the third group received hydro-alcoholic extract of Prosopis fracta seed extract (100 mg/kg orally) for 3 weeks. Serum liver enzymes and malondialdehyde (MDA) levels were assayed. After tissue processing, histopathological changes of liver were examined under light microscopy. Data were compared using one-way ANOVA and Tukey tests at the significance level of P Findings: Intraperitoneal injection of thioacetamide significantly increased liver enzymes in rats (P These results showed the protective effect of Prosopis farcta hydro-alcoholic extract on acute liver injury in rats.