MESNA Protective Effect against Cyclophosphamide Toxicity on Histomorphometry of Rat Placenta

Cyclophosphamide is a common chemotherapic medicine but it has toxic side effects. Different medicines are used to prevent its side effects. The aim of this study is evaluation of the protective effects of Mesna against cyclophosphamide toxicity in rat placenta tissue.
Fifteen pregnant rats were randomly divided into 3 groups (1) control (normal saline), (2) cyclophosphamide (15 mg/kg), (3) cyclophosphamide (15mg/kg) and Mesna (100mg/kg). Medicines were administered intraperitoneally on the 13th day of pregnancy. Rats were sacrificed on the 20th day. The placentae were separated and floated in fixative solution. Five µm placental tissue sections were prepared and after staining generally and specially they were studied by light microscopy. Cyclophosphamide decreased placental weight and diameters (P0.05) but histologically, increased labyrinth and basal layers thickness and giant cells number (P