Ameliorative effect of lithium chloride on working and spatial memory deficit in a PTZ-induced seizure model

The repetitive seizure attacks lead to widespread neuronal damage and cognitive deficit, e.g. memory and learning impairment. The single or repeated administration of pentylenetetrazole (PTZ) can induce seizure in rat. This study evaluates the neuroprotective effect of lithium chloride (LiCl) on PTZ-induced working and spatial memory deficit.
To induce the PTZ-kindling model, repeated doses of PTZ (40mg/kg/BW/ip) were injected for 5 consecutive days. After observing five stages of seizure, the PTZ⸭, PTZ⸮ and PTZⸯ groups received 20, 40 and 80 mg/kg/BW of LiCl, respectively and the PTZ䦩抝 group, received Saline for 14 days. The Morris water maze (MWM) and Y maze tests were conducted in order to investigate the spatial and working memory.
Compared to Control group, the PTZ䦩抝 group showed a decrease in alteration behavior in Y maze and an increase in latency time and distance to hidden platform in MWM. LiCl-treated rats, especially in the lowest dose, showed a significant higher alteration behavior in Y maze and the lower latency time and distance to hidden platform in MWM than the PTZ䦩抝 group.
The neuroprotective effects of LiCl can ameliorate the spatial and working memory impairment in a PTZ-kindling model.