The Histological Assessment of Acute Seizure on the Amygdala in Rat

Epilepsy is the most common neurological disorder. It has been suggested that recurrent seizure attacks may damage brain tissue. Dark neurons are known as unhealthy cells and obserevd in neurosurgical biopsies, experimental ischemia, hypoglycemia and epilepsy. This study was aimed to investigate probable neuronal damage in the amygdala after acute seizures induced by pentylenetetrazol (PTZ) in rat.
Male Wistar rats were divided into control, sham and PTZ groups. EEG recordings were performed before and after the PTZ injection. The number of dark neurons in the amygdala was measured and analysed in all different groups.
There was no significant difference in the number of dark neurons in the amygdala between PTZ, control and sham groups.
The result of present study showed that acute seizure may not damage neurons in the amygdala nuclei.