Effect of Aerobic Exercise and Caloric Restriction on Serum Adropin Levels and HOMA-IR in Obese Sedentary Women

The aim of this study was to compare the effects of aerobic exercise and caloric restriction on serum adropin levels, insulin resistance index (HOMA-IR) and anthropometric parameters in obese sedentary women. For this purpose, 30 obese sedentary women were recruited (Mean age: 40.2±5.4 year; weight: 77.9±7.1kg). Subjects randomly were divided into three groups for 16 weeks follow up: caloric restriction (experimental group 1 or CR), aerobic exercise with caloric restriction (experimental group 2 or EX) and control group. In CR group, subjects follow a diet with 25% caloric restriction. Subjects in CR group used a training program including aerobic exercise and running on treadmill for 66.85±5.34 minutes; 3 times a week and received a diet with 50% caloric restriction of CR group (12.5% caloric restriction.5% increase in energy expenditure). Before and after 16 weeks, blood sampling for measurement of serum adropin was carried out. Data were analyzed by paired sample t-test and one-way ANOVA at significant level of P