The Effects of Aerobic Training on Renal Oxidative Stress in Myocardial Infarction Rats

The aim of this study was the effects of 10 weeks aerobic training on oxidative stress in the kidney rats with myocardial infarction (MI). Four weeks after surgery, 24 male wistar rats randomly divided into three followed groups: sham surgery without MI (n=8), Control with myocardial infarction (Con-MI) and 3: Exercise training with myocardial infarction (Ex-MI). Ex-MI group running on a treadmill for 10 weeks (5 days per week, 50 min.day-1 with 17 m.min-1). While the sham and control groups throughout the period of the test intervention, did no exercise and were kept in cages. Catalase (Cat), glutathione peroxidase (GPx), reduced glutathione (GSH) as an antioxidant index and malondialdehyde (MDA) as a lipid peroxidation index were measured. Statistical analyses showed that the level of GPx was not significant difference among three experimental groups, but the levels of Cat and GSH were significantly lower in the Ex-MI and Con-MI groups compared with the Sham group. Also, there are no any different between Ex-MI and Con-MI groups with respects to the Cat and GSH activities. MDA levels significantly increased after myocardial infarction. In this regards analyses showed that MDA decreased in response to exercise training. These results demonstrated that ten weeks of moderate aerobic exercise intensity decreased renal stress oxidative by reducing lipid peroxidation levels and probably prevent the chronic renal failure in rats with myocardial infarction.