Effect of aqueous extract of eryngium campestre on the prevention of pathologic alterations caused by calcium oxalate crystals induced by ethylene glycol in the cortex and medulla of rat's kidneys
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Aim
Due to the effects of herbs in the prevention of kidney stones, the present study aimed at assessing the effect of aqueous eryngium campestre on the prevention of pathologic alterations caused by calcium oxalate crystals induced by ethylene glycol in the cortex and medulla of ratskidneys.Materials And Methods
To conduct the study 40 male Wistar rats, weighing 200 250 gr were randomly divided into 5 equal groups; i.e. the healthy control group that just received water, the negative control group receiving water with 1% ethylene glycol, the prevention groups, which in addition to 1% ethylene glycol in water were daily gavaged with 100 mg/kg, 200mg/kg, and 400 mg/kg of the plant extract. After 30 days all rats were killed and slides from each ones kidneys were prepared. The slides were stained applying H/E method and the number of their calcium oxalate crystals was checked.Results
It was found that there was a significant difference between the number of their calcium oxalate crystals in the control health and negative groups (P0.05). However, in the 200mg/kg prevention group compared to the negative control one there was a significant difference in reducing the number of the crystals (P0.05).Conclusion
It was discovered that aqueous extract of eryngium campestre is effective in preventing the accumulation of calcium oxalate crystals in the kidney. Keywords:
Language:
Persian
Published:
Birjand University of Medical Sciences, Volume:24 Issue: 2, 2017
Pages:
84 to 92
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