Epidemiologic Evaluation of Demographic and Basic Clinical Factors in Patients with Chronic Kidney Disease in Isfahan City, Iran, during 1996-2011

Chronic kidney disease (CKD) is a progressive disease. The prevalence of CKD continues to increase significantly due to increasing prevalence of diabetes and obesity and has been estimated 6.5 to 23.7 percent in Iran. The CKD progression may be largely due to secondary factors that are sometimes unrelated to the activity of the initial disease. These include demographic and clinical characteristics and the pattern of antihypertensive drug consumption.
This cross-sectional study was performed in autumn 2014 on 504 patients with chronic kidney disease in Isfahan City, Iran, during 1996-2011. Data on sex, weight, height, body mass index, antihypertensive drug, basic and mean annually blood pressure, underlying disease, proteinuria, serum creatinine, and Estimated Glomerular Filtration Rate (eGFR) were collected using a questionnaire.
Findings: 504 subjects (48.6% men and 51.4% women) with a mean age of 46.64 ± 17.06 years were enrolled in this study. Basic eGFR was 73.33 ± 32.05 ml/min/1.73 m2. Proteinuria was seen in 55.4% of patients. The prevalence of diabetes was 32.1%. Angiotensin converting enzyme (ACE) inhibitor was the most common drug class used by participants and accounted for 76.9% of the utilization; vasodilators were the least used antihypertensive drugs and represented as 0.6% of the total utilization.
The demographic and basic clinical characteristics of our study population nearly were similar to other studies in Iranian population, with these major differences that our participants were significantly younger, and the prevalence of diabetes and glomerulonephritis were higher in comparison to other studies. The utilization pattern of antihypertensive drugs had more accordance with clinical guidelines. The rate of eGFR reduction was significantly slow.