Relationship between the Frequency of rs4936742 Polymorphism of UBASH3B Gene and Behcet's Disease in the North West of Iran

Behcet's disease is an inflammatory disorder with an unknown cause. Various polymorphisms of ubiquitin signaling, including rs4936742 polymorphism of UBASH3B gene, are associated with Behcet’s disease. UBASH3B is involved in the negative regulation of downstream T cell receptor signaling pathways. The purpose of this study was to investigate the possible association of rs4936742 polymorphism of UBASH3B gene with Behcet’s disease in the North West of Iran.
This descriptive-analytic study was conducted on 70 patients suffering from Behcet’s disease and 60 healthy subjects living in the North West of Iran who were homogenous in terms of geographical region, age, and gender. The association of rs4936742 (T>C) polymorphism of UBASH3B was investigated using polymerase chain reaction-restriction fragment length polymorphism. The data were analyzed through Chi-square and Fisher’s exact tests.
According to the results, the frequencies of TT genotype were 24 (34.29%) and 11 (18.33%) cases in the patients and healthy controls, respectively (P=0.004). Furthermore, the frequencies of CC genotype were 14 (20%) and 27 (45%) cases in the patients and controls, respectively (P=0.0). T-allele frequencies in the patients and controls were 80 (57.15%) and 44 (36.67%) subjects, respectively (P=0.001). Additionally, C allele frequencies were 60 (42.85%) and 76 (63.33 %) cases in the patients and controls, respectively (P=0.002).
As the findings indicated, the individuals carrying TT genotypes of UBASH3 have 2.325 fold increased risk of developing Behcet’s disease, compared to those carrying non-TT genotypes.