Relationship between the Frequency of rs4936742 Polymorphism of UBASH3B Gene and Behcet's Disease in the North West of Iran
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objective
Behcet's disease is an inflammatory disorder with an unknown cause. Various polymorphisms of ubiquitin signaling, including rs4936742 polymorphism of UBASH3B gene, are associated with Behcets disease. UBASH3B is involved in the negative regulation of downstream T cell receptor signaling pathways. The purpose of this study was to investigate the possible association of rs4936742 polymorphism of UBASH3B gene with Behcets disease in the North West of Iran.Materials And Methods
This descriptive-analytic study was conducted on 70 patients suffering from Behcets disease and 60 healthy subjects living in the North West of Iran who were homogenous in terms of geographical region, age, and gender. The association of rs4936742 (T>C) polymorphism of UBASH3B was investigated using polymerase chain reaction-restriction fragment length polymorphism. The data were analyzed through Chi-square and Fishers exact tests.Results
According to the results, the frequencies of TT genotype were 24 (34.29%) and 11 (18.33%) cases in the patients and healthy controls, respectively (P=0.004). Furthermore, the frequencies of CC genotype were 14 (20%) and 27 (45%) cases in the patients and controls, respectively (P=0.0). T-allele frequencies in the patients and controls were 80 (57.15%) and 44 (36.67%) subjects, respectively (P=0.001). Additionally, C allele frequencies were 60 (42.85%) and 76 (63.33 %) cases in the patients and controls, respectively (P=0.002).Conclusion
As the findings indicated, the individuals carrying TT genotypes of UBASH3 have 2.325 fold increased risk of developing Behcets disease, compared to those carrying non-TT genotypes.Keywords:
Language:
Persian
Published:
Avicenna Journal of Clinical Medicine, Volume:24 Issue: 3, 2017
Pages:
229 to 235
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