The comparison of the effect of vitamin E on the expression of p53/PTEN of prostate gland of male rats in two groups of intensive continuous and intermittent exercise training

Physical activity and diet are the most important modifiable determinants of cancer risk. The aim of this study was to investigate the comparison of the effect of vitamin E on the expression of p53/PTEN prostate gland of male rats in two groups of intensive continuous and intermittent exercise training.
For this purpose, 56 male rats were randomly divided into 7 groups: [1] control group, [2] sham group, [3] intensive continuous training, [4] intensive intermittent training, [5] intensive continuous training vitamin E, [6] intensive intermittent training vitamin E, [7] vitamin E. The research training protocols were conducted in compliance with the principle of overload on the treadmill for six days a week, lasting 6 weeks. To measure expression changes of p53 and PTEN genes in rat's prostate, real-time PCR method was used and HPLC method was used to measure vitamin E. The One-way analysis of Variance test was used for comparisons among groups.
Vitamin E in combination with continuous training induced a significant decrease in the p53 gene expression of IIT VE group (p > 0/004) compared to the control group. In contrast, vitamin E in combination with intermittent training induced a significant decrease in expression of p53 (p>0/013) and a significant increase in the PTEN gene expression (p>0/035).
The results showed that physical exercise training reduced PTEN and p53 tumor suppressing gene expression by reducing oxidative stress, and vitamin E can be a somewhat increased expression of these genes.