Interactome Analysis of 11-Dehydrosinulariolide-Treated Oral Carcinoma Cell Lines Such as Ca9-22 and CAL-27 and Melanoma Cell Line

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in head and neck. The patients usually have a poor prognosis because they do not understand the significance of early symptoms. Then, the timely treatment may be lost. In recent years, network analysis is growing in the target identification concepts and can provide opportunities in pathway analysis. These could provide valuable information for drug development and progression monitoring of cancers such as OSCC.
PubMed Database was used as the main source and “Oral cancer” and “11-dehydrosinulariolide” and “Proteomics” were the keywords for the search process. We focused on articles that studied the differentially expressed proteins of cell lines of OSCC (Ca9-22 and CAL-27) and melanoma cell line (A2058) after 11-dehydrosinulariolideon treatment. The topological features of differentially expressed proteins were analyzed using Cytoscape Version 3.4.0. Module selection of the protein-protein interactions (PPI) networks was done using MCODE plug-in. In addition, gene ontology (GO) enrichment analysis of modules in related PPI networks was assessed.
Network analysis show that UBC, HSPA5 and GAPDH are the common central proteins between the three treated cell lines. The GO terms of the gene list of each of the correlated modules of networks are mostly related to four functions such as protein folding and assembly, metabolic processes, translation, and apoptotic pathways.
Despite introduction of different protein panels related to the effect of 11-dehydrosinulariolide on cancerous cell lines in the previous studies, here a common biomarker panel is represented.