Dickkopf-1 levels and serum Osteoprotegerin in women with Osteoporosis

In bone the Wnt signaling pathway has diverse roles in bone modeling and remodeling. Dickkopf related protein 1(DKK-1),as an end ogenous inhibitors of the canonical Wnt/β–catenin path ways pecific to bone and Osteoprotegerin(OPG),have been demonstrated to be key molecules involved in bone erosion and bone remodeling.The present study aimedto evaluate DKK-1 and OPG in women with osteoporosis to predict activity and severity of this common disease.
The study population included 44 women with osteoporosis and 44 controls with normal bone mineral density (BMD). Serum levels of DKK-1 and OPG were measured by standard methods.
The serum Dkk1 concentration in the osteoporosis group (2.91 ± 1.27) was significantly increased compared to the control group (2.07 ± 0.87) (P Although the results of this study indicate that DKK-1 and OPG may play different roles in the pathogenesis of osteoporosis, the increase of DKK-1 level and its correlation with FN-BMD might be related to disease activity and bone remodeling in osteoporosis.