In Vitro Antimicrobial Activity of New Substituted Phenylthiazole Derivatives
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
In this study, we evaluated antibacterial and antifungle activity of these derivatives against gram positive (Staphylococcus aureus, Bacillus subtilis, B. cereus), gram negative (Proteus vulgaris) bacteria and fungale (Candida albicans, C. tropicalis and C. glabrata).Methods
The broth macro dilution and well agar diffusion methods were used for determination of inhibition zoom (IZ) and minimum inhibitory concentration (MIC) during preliminary evaluation of antimicrobial activity.Results
The (MIC) values of tested compounds revealed that all compounds were active against Staphylococcus oureus and exhibited the same antibacterial activity in comparison to ceftizoxim (MIC=125µg/mL). The results of antifungal screening showed that all the compounds were potent antimicrobial activity against tested pathogenic fungi (MIC=250 to1000 µg/ml). Compounds (6a) and (6b) showed the maximum activity with MIC value of 250 µg/ml against all tested fungi, but compound (6h) showed poor antifungal activity against all fungi. MIC values for title compounds were similar to MIC results for fluconazol.Conclusions
All the compounds are potent antifungal and antibacterial activity against tested microorganism. Keywords:
Language:
English
Published:
Iranian Journal of Toxicology, Volume:12 Issue: 1, Jan-Fab 2018
Pages:
33 to 37
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