Effects of Oral Sodium Nitrate Administration on Cell Blood Count in Obese Type 2 Diabetic Male Rats

Type 2 diabetes is one of the most common metabolic diseases. Nitrate has been introduced as a new therapeutic agent for type 2 diabetes. Considering that both diabetes and nitrate have some effects on blood cell count and 30% of diabetic patients have anemia, the aim of this study was to determine the effect of sodium nitrate on blood cell count in obese type 2 diabetic rats.
Forty-eight male Wistar rats were divided into four groups: Control, Control nitrate, Diabetes and Diabetes nitrate. The groups that received nitrate (Control nitrate, Diabetes nitrate) again were divided into two subgroups, which received sodium nitrate (100 and 250 mg/L in drinking water) for two months: control鸫歪ힵ (CN100), control鸫歪 250 (CN250), diabetes鸫歪ힵ (DN100), and diabetes鸫歪ힶ (DN250). Diabetes was induced using a high-fat diet for 14 days and injection of streptozotocin. Blood cell count was performed at the end of the study.
In diabetic rats, nitrate administration reduced body weight, blood glucose, hematocrits, and neutrophils (all p Administration of sodium nitrate, which is considered as a therapeutic agent in type 2 diabetes, decreased blood glucose in the type 2 diabetic rats but had no major harmful effects on blood parameters; in addition, it may also have anti-inflammatory effects by decreasing the number of neutrophils.