Changes in Cardiac Levels of Caspase-8, Bcl-2 and Heart Wall Stress Following 4 Weeks of Running Aerobic Exercise in Diabetic Rats

Introduction and aim: Cardiac apoptosis is one of the most important cardiovascular effects of diabetes. The aim of this study was to investigate changes in cardiac levels of caspase-8, Bcl-2and cardiac wall stress after 4 weeks of aerobic exercise in male rats with diabetes.
40 adult male rats were randomly assigned to healthy control, Diabetes, healthy exercise and exercise瘦魺힬. Diabetic was induced by intraperitoneal injection of Streptozotocin solution (55 mg / kg). Two weeks after injection, fasting blood glucose levels were measured. After determining the induction of diabetes, the exercise program was performed for 4 weeks (5 sessions per week) at a speed of 18-15 m/min and 25-44 min. 48 hours after the last training session, the subjects were anesthetized and the heart muscle was removed. Caspase-8, Bcl-2 and NT-proBNP levels were measured by ELISA method.
The induction of diabetes in the control group resulted in a significant increase in Caspase-8, NT-proBNP levels and insignificant Bcl-2 levels (p The results of this study showed that diabetes increases the pre-apoptotic and cardiac cell wall stress levels and reduces the anti-apoptosis agent and possibly 4-weeks regular aerobic exercises can be used as a non-pharmacological strategy to reduce the complications of apoptosis in diabetes mellitus Cardiomyocytes.