Insidence Rate and Risk Factors of Seizure Recurrence without Taking Medication in the 6-Month Period after the First Attack

Seizure is one of the important reasons for referral to the emergency department, which sometimes indicates serious damage to the brain parenchyma. Since in patients without a history, awareness of the medium-term course of the disease helps the diagnosis, thus, in this study, definition of 6-month prognosis without taking medication, was investigated after the first seizure attack.
This study is an observational cohort study. The sample population included 125 patients, who referred to the emergency of Rasoul Akram Hospital after the first seizure attack, and had no recent history of consumption of anticoagulants, alcohol, narcotics, and psychotropic drugs. Sampling method was consecutive sampling. Data were analyzed using Chi-square, independent t-, and logistic regression analytical tests. The significance level was considered as p During the 6-month follow-up, 30.4% of the patients had seizure recurrence. Among the patients referred to the emergency department with first seizure, the number of men was significantly higher than women. Also, a significant difference was observed between two genders and family history or seizure recurrence in the follow-up period.
The results of this study indicated that factors, such as gender, presence of status epilepticus and, first-grade family history of seizures can be considered as the risk factors for seizure recurrence in the 6-month period after the first seizure without taking medication. Therefore, considering these variables and appropriate treatment, the incidence rate of seizures significantly decreases after discharge from hospital.