Lipid profile, interlukin-6 and tumor necrosis factor-α changes following 8 weeks aerobic exercises in male rats,

Aerobic exercises are considered as an affecting factor on inflammatory indices and lipid profile. The present study examined the effect of aerobic exercises on IL-6 and TNF-α proteins and lipid profile in Male Rats. For this purpose, 18 healthy adult male rats were selected and divided into two groups: control groups (N = 8) and subjects groups (N = 10). Aerobic exercise protocol was carried out during 8 weeks period, 3 sessions per weeks and 27 to 32 minutes per session by the intensity of 60-80% of VO2max(speed 8-25 m /min) on the treadmill in a zero gradient. After 8 weeks blood and tissue sampling was performed.Levels of IL-6 (p = 0/01) decreased significantly in trained rats compared with controls groups. While there were no significant difference in TNF-α levels. On the other hand, total serum cholesterol (P = 0/004) decreased followed by aerobic exercise. However, changes in the other lipid profile indices were not significant. Therefore, we can conclude that Aerobic exercise may lead to reduced inflammatory response and improve the lipid profile indices.