Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice

Coriandrum sativum L (CS) has different pharmacological properties such as analgesic, anti-inflammatory, and anti-stress effects. Hence, in the present study the effects of CS essential oil on naloxone -induced jumping in morphine-dependent mice was investigated.
Material & In this experimental study, 60 male albino mice were used. The animals were divided into 10 groups of 6, including carrier (10 ml/kg), clonidine (3.5 mg/kg), and different doses of CS essential oil (400, 600, and 800 mg/kg). Tolerance and dependency on morphine were induced by administration of different doses of morphine (50, 50, 75, and 50 mg/kg, respectively) in a 4-day schedule. On the last day, after administration of single dose of morphine, Naloxone (5 mg /kg) was injected and the number of jumps was recorded within 30 minutes.
Results showed that all doses of CS essential oil and clonidine, compared to control group, significantly decreased the number of jumping in both tolerance and dependence stage (P Based on present study findings, it is concluded that, probably the existing linalool in CS could decrease the number of jumps from tolerance and dependence in morphine- dependent mice. Of course, further studies are required to clarify their exact mechanism of action.