Benidipine reduces ischemia/reperfusion injury following testicular torsion/detorsion in rats

Objective-This study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in ratsDesign-Experimental study
Animals-Fifteen male Sprague-Dawly rats weighing 200-220g
Procedure-Rats were randomly divided into 3 groups: sham (healthy group with sham operation, n=5), IRC group (control group in which I/R injury was performed by torsion the right testis 720 º clockwise for 2 hours and detorsion for 2 hours, n=5), and IRB group (IR benidipine, I/R process was performed following orally benidipine administration 4 mg/kg benidipine, n=5). Levels of glutathione peroxidase (GPx) and malondialdehyde (MDA) were determined in testicular tissues of rats. Testicular tissues were also examined histopathologically.
Results-The levels of MDA (PConclusion and clinical relevance-These results show that therapy with benidipine before torsion may induce protective effects against ischemia/reperfusion injury