The effect of bioactive peptides mixture extracted from sardine on total antioxidant capacity of serum, lipid peroxidation and blood parameters in rats exposed to restraint stress

Todays, chemical drugs such as fluoxetine with different side effects are used to reduce stress effects. In the current study, the effects of Bioactive peptides from fermented sardine fish mixture on the total antioxidant capacity (TAC) and lipid peroxidation (MDA) of plasma and blood parameters as well was investigated in comparison with Fluoxetine in restrained male rat. Thirty healthy male rats (100 ± 20 g) were randomly distributed in 6 cages at a density of 5 rat/cage and treated experimental groups (Control C, 2 hours restrained per day S, Bioactive peptides P, Fluoxetine F, S, S. After 21 days, the results indicated that the lowest TAC and highest MDA was observes in restrained rats than control and S (P0.05). The red blood cells, hematocrit and hemoglobin significantly increased in restrained rats than control and S (P