The Effect of Ethanol Baneh Skin Extract on the Expressions of Bcl - 2, Bax, and Caspase - 3 Concentration in Human Prostate Cancer pc3 Cells

Traditional herbs are effective in the treatment of many diseases. It is proven that traditional herbs can decrease the risk of cancer and grow the survivals of patients.
Based on the results of our previous research, ethanol Baneh skin extract has cytotoxic effect on pc3 cells; thus, we decide to determine the effect of Baneh extracts on Bcl2 and Bax expression and amount of concentration of caspase3.
The expressions of apoptotic - related genes were determined by real time PCR and the concentration of caspase3 was determined by ELISA method.
Ethanol Baneh skin extract increased the mRNA expression of Bax and decreased the mRNA expression of Bcl2 in pc3 cells and also increased the amount of caspase3.
The result of this study indicates the Ethanol Baneh skin extract including photochemical that might be a candidate for the herbal anti - cancer drugs.