Study of histopathology and bioaccumulation of Iron oxide (Fe2O3) nanoparticles in liver of common carp (Cyprinus carpio)

Increasing production of nanoparticles and its usage in different industries has led concerns about its dangers and toxicity in the environment, but there is not enough information about their toxicity effects, and their safety is unknown. This study tried to evaluate the bioaccumulation and histopathology of iron oxide nanoparticles (Fe2O3) in liver tissues of Common carp (Cyprinus carpio). To this aim, Common carp fishes were prepared from a fish farm and transferred to the laboratory. After adapting to the laboratory conditions for a week, the fishes were divided into 4 treatments. The first treatment was considered as control and the other treatments received 50, 75 and the 100 milligrams per liter of iron oxide nanoparticles. In the days 14, 21 and 28, the fishes were randomly selected from each treatment and the liver tissues were separated and were examined for bioaccumulation and histopathology. In the present study the result of the statistical analysis showed in the day 21 of the experiment, the concentration of Iron was significantly higher than other treatments in the liver. Histopathological examination in liver showed the most lesions in treatment 4 in day28 included severe necrosis and vacuolar degeneration, infiltration of inflammatory cells mild and hyperemia. The results of present study showed by increasing of dose and exposure time of iron oxide nanoparticles (Fe2O3) the lesions in hepatocytes increased and iron concentration in liver decreased.