Evaluating the Effect of Duloxetine on Morphine-Induced Dependence and Tolerance to Its Analgesic Effects in Mice

Despite the analgesic effects of morphine, its chronic use leads to tolerance and dependence, and duloxetine can change the rate of dependence and tolerance. This study aimed to investigate the effect of duloxetine on morphine-induced dependence and tolerance to its analgesic effects in mice.
In the present experimental study, male mice were randomly put in 37 groups of 8. Jumping and diarrhea of the animals, at the time of withdrawal syndrome (naloxone prescription), was evaluated in two development (duloxetine±morphine) and expression (duloxetine prescription before withdrawal syndrome) factors at the 10, 20, and 30 mg/kg/bw doses of duloxetine. Moreover, open field and tail-flick test were utilized to examine the duloxetine effect on locomotor activity and tolerance to the analgesic effects of morphine, respectively. The data were analyzed using one-way analysis of variance (ANOVA) and Dunnett’s post hoc test.
Duloxetine at the dose of 30 mg/kg/bw decreased jumping and locomotor activity of the animal (p Duloxetine reduced withdrawal signs in the expression of dependence test, but it did not have any effect on tolerance to analgesic effects of morphine.