The Interaction Between Some Nutrients and CCND2, ZNT8, and MC4R Polymorphisms in Relation to Metabolic Syndrome and Its Components

Background and This study aimed at examining the interaction between macronutrients, some micronutrients (magnesium, zinc, iron, calcium, and copper) and CCND2 rs11063069, ZNT8 rs13266634, and MC4R rs12970134 polymorphisms in relation to metabolic syndrome (MetS) and its components.
In this matched nested case-control study, the data for 1634 (817 pairs) case (the new cases of metabolic syndrome) and controls (healthy individuals without metabolic syndrome) were obtained from the Tehran Lipid and Glucose Study.
The participants were matched on age, sex, and follow-up years. Dietary intakes were assessed using the Food Frequency Questionnaire (FFQ). The polymorphisms were genotyped by ARMS-PCR.
Saturated fatty acid and omega-3 fatty acid could modulate the association of MC4R and ZNT8 variant with MetS, respectively (Pi According to our findings, low fat diets are recommended in A allele carriers of MC4R rs12970134, while a diet rich in omega-3 and zinc is more appropriate for C allele carriers of ZNT8 rs13266634.