Control of bacterial infections in knee implants

total Knee arthroplasty is an effective and cost-reducing therapeutic approach, which is very useful in relieving pain and improving the performance of patients with advanced knee arthritis, but there are some factors that may lead to the failure of this surgery. From that which patients need for re-surgical repair, the most common causes of knee replacement are included as infection, poor mechanized joint replacement, implant failure, or frailty of implant. Infection is the most common cause of the main cause Knee replacement surgery. The main goal in this study is to explore new procedures to reduce implant-induced defects and also increase the implants life in knee arthroplasty surgery.
search was carried out in PubMed, science direct and magazine of materials for identification of published articles and studies on infections caused by bone implants. 76 articles were reviewed from 2003 to 2016 and 50 articles of them were cited in the text.
From the 50 papers cited in this study, 41 articles examined the effects of non-antibiotics on infections of bone implants. 5 papers have been reviewed carefully for non-antibiotic treatments and their effects on bone tissue in vitro and 4 are related to combination of these agents with antibiotics and subsequent increase in their efficacy after surgery.
Using of non-antibiotic agents to preventing cause infections after knee surgery intended to preventing biofilm formation in this area is one of the methods suggested to prevent antibiotic resistance against antibiotics.
Today, in these surgeries, polyethylmetacrylate cements are commonly used filled with antibiotics such as vancomycin and gentamicin, which unaccustomedly may be exposed by bacteria and biofilms, and ultimately lead to acute infections. Our overview is exploring the technologies that can improve the performance of orthopedic implants, which may reduce the severity of knee joint infections. The results of these reports also have revealed that the combination of technology and different types of infections at the same time, can promote microbial infection Cause.