An Effective Herbal Compound on Asthma; Based on Iranian Traditional Medicine

Asthma Diagnosis based on the clinical signs, such as wheezing, family history of asthma, eczema, and allergic rhinitis. The side effects, high cost and use of preservatives and flavoring agents in synthetic chemical compounds have led to increasing interest towards using herbs. The Flavonoids of licorice (Glycyrrhiza glabra) have anti-inflammatory effects. These flavonoids are chemokine, involved in eosinophil migration into the lung. Moreover, they inhibit phosphofiesterase (PDE) and increase the cGMP that leads opening of BKca channels and thus tracheal relaxation. Viola odorata considerably repressed the total serum level of IgE. As a result, IL-3 and IL-4 effectively decrease over-response of the airways and eosinophilia and excessive secretion of mucus. Extract of Operculina turpethum possesses antispasmodic activities, which is dependent upon an increase in the cytoplasmic free calcium. The presence of flavonoids such as saponin and tannins are responsible for Operculina turpethum antispasmodic activities in gastrointestinal and respiratory tract.