Histological Analysis of Three Types of Allografts (FDBA, DFDBA, Partial) on Bone Repair Quality and Quantity of Artificially Created Defects in Rabbit Calvarium

FDBA, DFDBA and PARTIAL allografts are widely used as bone substitute materials. The aim of this study was to histologically compare the regenerative features of these three types of allografts manufactured by Kish Hamanandsaz Company in Iran. In this experimental animal study, four bone defects with a diameter of 8 mm and a depth of approximately 1 mm were produced in the calvaria of 8 rabbits (4 defects in each rabbit) by trephine. In three defects, three types of allografts, i.e. FDBA, DFDBA and PARTIAL, were placed and one defect served as a control. One of the rabbits died 5 days after surgery. Histological samples were prepared after 4 weeks. Percentages of new bone formation and the remaining materials and inflammation were evaluated. Data were analyzed with Friedman and Cochran tests, using SPSS 22 (α = 0.05). There were significant differences between the four groups (DFDBA, FDBA, PARTIAL and control) in mean percentages of new bone formation (p value = 0.001) and mean percentages of remaining material (p value = 0.002). However, there were no significant differences in inflammation between the four groups (p value = 0.572). Despite the difference in numerical values for bone regeneration, there were no statistically significant differences in the amount of bone formation between DFDBA and FDBA groups, but further studies are necessary on PARTIAL allograft