Comparison the Effect of Ciprofloxacin Versus Amoxicillin and Metronidazole as an Adjunctive Therapy to Full Mouth Scaling and Root Planing of Chronic Periodontitis

So many people worldwide have chronic periodontitis. Chemotherapeutic agents can reduce host responses to bacterial pathogens and as a result reduce bone loss. The aim of this study was to compare the effect of antibiotics such as amoxicillin and metronidazole (AMX+MTZ) with ciprofloxacin (CPF) as an adjunct to scaling and root planing (SRP) in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic periodontitis. In this randomized double-blinded placebo-controlled clinical trials, 45 patients with chronic moderate to severe periodontitis were randomly divided into 3 groups: the control group which received SRP plus placebo, the test 1 group which received SRP plus AMX+MTZ, and the test 2 group which received SRP plus CPF. PD and CAL were measured in each group at 3 time points (baseline, 1 month and 3 months after SRP). Statistical analysis was done using a paired t test and ANOVA. Mean PD and CAL in the test groups were compared to the control group and no significant changes were found (P<0.05). Most changes in PD and CAL were seen at one month after intervention. Better outcomes were seen in the test groups (test 2 better than test 1). AMX+MTZ or CPF as an adjunct to SRP had better outcomes but did not have any significant impact on reducing PD and CAL over one 1 and 3 months after treatment in patients with chronic periodontitis.